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Aptima Trichomonas Vaginalis Assay

With the development of the Aptima Trichomonas vaginalis (TV) test, laboratories and clinicians now have a highly specific assay that detects up to 100% of trichomonas infections.1 Moreover, a TV infection can be detected with only a fraction of a single organism present in the sample for detection, while up to 50% are missed by wet mount.The Aptima TV test can be ordered alone or along with the Aptima Combo 2 test for Chlamydia and Gonorrhea testing.


The Aptima Trichomonas vaginalis assay is a nucleic acid test that, like the Aptima Combo 2 assay, utilizes target capture, transcription-mediated amplification and hybridization protection assay technologies. It allows healthcare providers to test a variety of specimens, including endocervical swabs, vaginal swabs, female urine specimens and specimens collected in PreservCyt solution (the ThinPrep Pap test).

With only a fraction of a single organism required for detection, this assay overcomes the challenges associated with current slow, less sensitive culture methods and "wet mounts," which require the microscopic examination of a sample shortly after it is collected and are even less sensitive than culture. The Aptima Trichomonas vaginalis assay is currently available for use on the Panther and Tigris automated test platforms.



Trichomonas vaginalis is more prevalent than chlamydia and gonorrhea –- yet like those common STIs, the majority of infected people have no symptoms.2-3 In the 30% who do show symptoms, they can range from mild to severe. Trichomoniasis can also increase the risk of getting or spreading other STIs. In pregnant women, it can cause premature rupturing of the membranes protecting the baby, potentially triggering early delivery.4

Caused by the parasite Trichomonas vaginalis, trichomoniasis is the most common curable STI. One in 10 women over the age of 40 have been infected with trichomonas, and the highest prevalence of trichomonas infections is in women between the ages of 35-45.5 Pregnant women with trichomoniasis are more likely to deliver their babies preterm. Babies born to women infected with trichomonas are more likely to be born at a lower birth weight (under 5.5 lbs), which can result in cognitive disorders, inhibited growth and chronic diseases later in life. The parasite also causes genital inflammation, which can increase the chance of becoming infected with the HIV virus.1

  1. Huppert, et al., CID2007:45 (15 July).
  2. CDC Fact Sheet Incidence, Prevalence and Cost of Sexually Transmitted Infections in the United States.
  3. CDC Trichomoniasis Fact Sheet:
  4. CDC Sexually Transmitted Disease Treatment Guidelines, 2010.
  5. Ginocchio, et al. Prevalence of Trichomonas vaginalis and coinfection with Chlamydia trachomatis and Neisseria gonorrhoeae in the United States as determined by the Aptima trichomonas vaginalis nucleic acid amplification assay. J. Clin. Microbiol. August 2012 vol. 50 no. 8 2601-2608.